General elections will be held in Nicaragua on 7 November 2021 to elect the President, the National Assembly and members of the Central American Parliament.

President Daniel Ortega, of the Sandinista National Liberation Front, is seeking re-election. In June 2021, the government arrested five opposition pre-candidates for president: Cristiana Chamorro Barrios, Arturo Cruz Jr., Félix Maradiaga, Juan Sebastián Chamorro and Miguel Mora. In July Medardo Mairena and Noel Vidaurre were arrested, and Luis Fley and María Asunción Moreno went into exile citing threats of arrest.

Candidates registered on August 2, 2021. On August 3, vice-presidential candidate Berenice Quezada was placed under house arrest and disqualified. Her party, Citizens for Liberty, and its presidential candidate Oscar Sobalvarro, had their legal status suspended by the Supreme Electoral Council the following week and Constitutionalist Liberal Party candidate Milton Arcia resigned in protest.